Faecal Microbiota Transplant (FMT) Therapy

Introduction to FMT

Faecal Microbiota Transplantation (FMT) is an advanced treatment designed to restore a healthy balance of gut bacteria by introducing carefully screened donor microbiota into the patient’s gastrointestinal tract. At the Centre for Gut and Brain Axis (C-GABA), FMT is delivered within a structured, evidence-based programme that integrates microbiome science, gastrointestinal expertise, and personalised patient care.

FMT is one of the most effective treatments for recurrent Clostridioides difficile infection (C. diff) and is increasingly studied as a supportive therapy for conditions associated with gut dysbiosis and gut–brain axis imbalance.

How FMT Works

Your gut microbiome contains trillions of beneficial bacteria essential for digestion, immunity, inflammation control, and communication with the brain. When this natural balance becomes disrupted, a condition known as dysbiosis, symptoms and chronic disorders may develop.

FMT works by:

• Replenishing beneficial bacteria
• Restoring microbial diversity
• Strengthening the gut barrier and immune function
• Reducing inflammation
• Supporting gut–brain axis signalling

The end goal is to help re-establish a stable, healthy microbiome that can regulate digestive and systemic function more effectively.

Conditions FMT May Support

While FMT is clinically established for recurrent C. difficile infection, research and global clinical experience suggest benefits in selected cases of:

• Ulcerative colitis
• Crohn’s disease
• Irritable Bowel Syndrome (IBS)
• Severe or chronic dysbiosis
• Autism spectrum disorder (microbiome-related protocols)
• Constipation-dominant disorders
• Gut–Brain Axis–related symptoms (fatigue, anxiety, mood changes)

Dr. Srinivasaiah carefully evaluates each patient to determine whether FMT is appropriate as a primary or adjunct treatment.

Our FMT Process at C-GABA

1. Initial Consultation & Diagnostic Workup

• Medical evaluation
• Stool microbiome analysis
• Functional medicine review
• Psychology review
• Colonoscopy +Biopsy
• Allergy test(if needed)
• Dietary review
• Blood tests, stool test and inflammatory markers
• Review of previous treatments

2. Personalised Treatment Planning

Based on clinical findings, we determine suitability for FMT and create a tailored treatment pathway.

3. Donor Screening & Microbiome Preparation

Donors undergo extensive medical, microbiological, and lifestyle screening. Microbiota material is processed in a controlled setting to ensure safety and consistency.

4. FMT Administration

FMT may be delivered through:

• Colonoscopy
• Upper-GI routes (selected cases)

The method is chosen based on each patient’s condition and diagnostic profile.

Post-Treatment Monitoring

Patients receive follow-up assessment, microbiome monitoring, and symptom tracking to support long-term improvement.

Frequently Asked Questions (FAQs)

What conditions are approved for FMT?

Clinically, FMT is primarily established for recurrent C. difficile infection. However, ongoing research supports its potential benefit in ulcerative colitis, IBS, Crohn’s disease, chronic dysbiosis, and certain gut–brain axis disorders. Suitability is assessed individually.

Is FMT safe?

Yes, when performed with strict donor screening and clinical oversight. At C-GABA, donors undergo comprehensive testing, and all procedures adhere to stringent safety protocols.

How quickly does FMT work?

Some patients notice improvement within days, while others experience gradual changes over several weeks. Long-term benefits depend on microbiome integration, lifestyle, and underlying conditions.

How is the donor selected?

Donors are screened for:

• Infectious diseases
• Gastrointestinal disorders
• No recent antibiotics
• No allergy to any food and medicine
• Metabolic and autoimmune conditions
• Diet and lifestyle factors
• No stressful life
• Microbiome diversity

How many sessions do I need?

The number of FMT sessions varies. Recurrent C. diff often requires a single treatment, while chronic or complex conditions may benefit from multiple administrations based on clinical evaluation.

Is the procedure uncomfortable?

Most patients tolerate FMT very well. Colonoscopic delivery is typically done with or without  sedation. 

Can FMT help with mental health conditions?

Emerging research suggests a strong connection between gut microbiota and brain function. While evidence is evolving, improvements in anxiety, mood regulation, and cognitive symptoms have been reported in some cases. FMT is considered supportive rather than primary treatment.

Are results permanent?

FMT can create long-lasting microbiome changes. However, diet, antibiotics, stress, and illness can influence the gut microbiome over time. We provide guidance to help maintain long-term benefits.

Is FMT right for me?

Suitability depends on your medical history, microbiome assessment, and current symptoms. A full consultation with Dr. Srinivasaiah is the best way to determine if FMT is appropriate for your condition.